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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG10825.50 | 50 µg | - | - |
6 - 14 business days* |
528.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Adhesion molecule that mediates interactions between myelinating cells and... more
Product information "Anti-MAG"
Protein function: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid- containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury, protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults, this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth, in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth. Inhibits axon outgrowth by binding to RTN4R. Preferentially binds to alpha- 2,3-linked sialic acid. Binds ganglioside Gt1b. [The UniProt Consortium]
Keywords: | Anti-MAG, Anti-GMA, Anti-Siglec-4a, Anti-Myelin-associated glycoprotein |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG10825 |
Properties
Application: | IHC (paraffin), WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse, rat (Expected: human) |
Immunogen: | aa. 114-132 (KYYFRGDLGGYNQYTFSEH)(100% homologous in Human, Mouse and Rat) |
MW: | 100 kD |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K06771 | Matching products |
UniProt ID : | P20916 | Matching products |
Gene ID | GeneID 4099 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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