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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-11-8065-25 | 25 µg | - |
3 - 11 business days* |
134.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Musculoaponeurotic fibrosarcoma oncogene family A (MafA) is a pancreatic transcriptional factor... more
Product information "Anti-Mafa"
Musculoaponeurotic fibrosarcoma oncogene family A (MafA) is a pancreatic transcriptional factor that is important to pancreatic beta-cell function. It is a member of the musculo-aponeurotic fibrosarcoma oncogene family, a subgroup of the basic leucine zipper transcription factors with homology to the v-Maf oncoprotein. It acts as a transcriptional regulator that promotes the expression of genes important in glucose-induced insulin secretion, such as insulin, glucokinase and glucose transporter protein-2. Mafa is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet beta-cells thus may be involved in pathogenesis of diabetes. Protein function: Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498). [The UniProt Consortium]
Keywords: | Anti-MAFA, Anti-RIPE3b1 factor, Anti-Transcription factor MafA, Anti-Pancreatic beta-cell-specific transcriptional activator, Anti-V-maf musculoaponeurotic fibrosarcoma oncogene homolog A, Polyclonal Antibody to Mafa |
Supplier: | Abeomics |
Supplier-Nr: | 11-8065-25 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: mouse) |
Immunogen: | A partial length recombinant Mafa protein (amino acids 192-353) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K07595 | Matching products |
UniProt ID : | Q8NHW3 | Matching products |
Gene ID | GeneID 389692 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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