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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
L4725-50D.100 | 100 µg | - | - |
3 - 19 business days* |
962.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
LTK is a glycoprotein member of the tyrosine protein kinase family, insulin receptor subfamily of... more
Product information "Anti-LTK (Leukocyte Tyrosine Kinase Receptor, Protein Tyrosine Kinase 1, TYK1)"
LTK is a glycoprotein member of the tyrosine protein kinase family, insulin receptor subfamily of proteins. There are multiple isoforms that run between 50 and 100kD in SDS-Page. It is reportedly expressed in lymphocytes and cerebral cortex neurons, plus cardiomyocytes where it plays a role in cellular hypertrophy. Mature human LTK is an 848aa type I transmembrane protein that is embedded in the ER. It contains a 408aa extracellular domain aa17-424 plus a 415aa cytoplasmic region aa450-864. The cytoplasmic region possesses multiple phosphotyrosines that interact with downstream signaling molecules. There is also a protein kinase domain between aa510-786. LTK apparently undergoes dimer- and trimerization under certain circumstances. There are multiple splice variants for LTK. Two isoforms possess a common deletion of aa274-334 that may be accompanied by a 27aa substitution for aa449-544. Another isoform shows an alternative start site at aa406 accompanied by a 17aa substitution for aa449, while a fourth isoform contains a 51aa substitution for aa171-864. A final 50kD isoform shows a 28aa substitution for aa449-864. Over aa17-424, human LTK shares 75% aa identity with mouse LTK. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml, Immunohistochemistry: 5-15ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-LTK, Anti-TYK1, EC=2.7.10.1, Anti-Protein tyrosine kinase 1, Anti-Leukocyte tyrosine kinase receptor |
Supplier: | United States Biological |
Supplier-Nr: | L4725-50D |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Sheep |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to aa10-424 from human LTK expressed in NSO cell line. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05118 | Matching products |
UniProt ID : | P29376 | Matching products |
Gene ID | GeneID 4058 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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