Anti-LPAM-1 (Lymphocyte Peyer's patch Adhesion Molecule 1, Integrin alpha4,beta7), Biotin conjugated

The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as integrin alpha4beta7, is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The a4b7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM-1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. This antibody recognizes a conformational epitope on the heterodimer. 2, Applications:  Flow cytometry 1-4,  Blockade of binding to cell adhesion molecules 1,  Induction of homotypic cellular aggregation 1,  Immunohistochemistry (frozen sections) 3, Recommended Dilution: Flow Cytometry: < 1ug/10e6 cells, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.