Anti-Lewis b, clone 2-25LE or LWB01

Anti-Lewis b, clone 2-25LE or LWB01
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3146SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. The Lewis histo-blood group system comprises... more
Product information "Anti-Lewis b, clone 2-25LE or LWB01"
1 mg/ml in sterile PBS, BSA free, sodium azide free. The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers. Protein function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination, Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links. [The UniProt Consortium]
Keywords: Anti-FT3B, Anti-FUT3, Anti-Lewis FT, Anti-FucT-III, EC=2.4.1.65, Anti-Fucosyltransferase 3, Anti-Fucosyltransferase III, Anti-Galactoside 3(4)-L-fucosyltransferase, Anti-Blood group Lewis alpha-4-fucosyltransferase, Lewis b Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3146SAF-100UG

Properties

Application: IF, IHC
Antibody Type: Monoclonal
Clone: 2-25LE / LWB01
Conjugate: No
Host: Mouse
Reactivity: Human, Guinea Swine
Immunogen: Mucin isolated from human ovarian cyst fluid was used as the immunogen for this Lewis b antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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