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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-CAB10761.50 | 50 µl | - | - |
9 - 20 business days* |
352.00€
|
||
G-CAB10761.100 | 100 µl | - |
9 - 20 business days* |
448.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
WB 1:500 - 1:2000. Protein function: Required for optimal lysosomal function (PubMed:21224396).... more
Product information "Anti-LAPTM4B"
WB 1:500 - 1:2000. Protein function: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656). [The UniProt Consortium]
Keywords: | Anti-PSEC0001, Anti-Lysosomal-associated transmembrane protein 4B, Anti-Lysosome-associated transmembrane protein 4-beta, LAPTM4B Polyclonal Antibody (CAB10761) |
Supplier: | Assay Genie |
Supplier-Nr: | CAB10761 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Database Information
KEGG ID : | K12387 | Matching products |
UniProt ID : | Q86VI4 | Matching products |
Gene ID | GeneID 55353 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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