Anti-KPNA1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-CF9 100 µg - -

6 - 10 business days*

684.00€
 
Anti-KPNA1 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-KPNA1"
Anti-KPNA1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with KPNA1 from other sources has not been determined. Protein function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. [The UniProt Consortium]
Keywords: Anti-RCH2, Anti-KPNA1
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-CF9

Properties

Application: ELISA, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: 15 amino acid synthetic peptide near the N-terminus of human KPNA1.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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