Anti-KLHL3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA051291.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA051291.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex... more

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Product information "Anti-KLHL3"

Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight- junction protein required for paracellular chloride transport in the kidney. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 69% and to rat: 63%

Keywords:	Anti-Kelch-like protein 3
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA051291

Properties

Application:	IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: MEGESVKLSS QTLIQAGDDE KNQRTITVNP AH (ATA-APrEST85566)