Anti-KLHL25

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA023450.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA023450.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex... more

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Product information "Anti-KLHL25"

Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 87% and to rat: 88%

Keywords:	Anti-ENC2, Anti-ENC-2, Anti-KLHL25, Anti-Kelch-like protein 25, Anti-Ectoderm-neural cortex protein 2
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA023450

Properties

Application:	ICC, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: HFETVRQSED FNSLSKDTLL DLISSDELET EDERVVFEAI LQWVKHDLEP RKVHLPELLR SVRLALLPSD CLQEAVSSEA LLMADERTKL IMDEALRCKT RILQNDGVVT SPCA (ATA-APrEST76071)