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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R30860 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Kallikrein-related peptidase 6 is a... more
Product information "Anti-Kallikrein 6"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Kallikrein-related peptidase 6 is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimers disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies. Protein function: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. [The UniProt Consortium]
Keywords: | Anti-KLK6, Anti-SP59, Anti-Zyme, Anti-PRSS18, Anti-Neurosin, Anti-Protease M, EC=3.4.21.-, Anti-Kallikrein-6, Anti-Serine protease 9, Anti-Serine protease 18, Kallikrein 6 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R30860 |
Properties
Application: | WB, IHC (paraffin), ICC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | An amino acid sequence from the C-terminus of human KLK6 (YTNVCRYTNWIQKTIQAK) was used as the immunogen for this Kallikrein 6 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K08667 | Matching products |
UniProt ID : | Q92876 | Matching products |
Gene ID | GeneID 5653 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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