Anti-K1737

Protein function: Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Nucleus . Cytoplasm, cytosol . Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol. .