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The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. Protein function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. [The UniProt Consortium]
Keywords:
JMJD1C, JHDM2C, TRIP-8, EC=1.14.11.-, TR-interacting protein 8, Jumonji domain-containing protein 1C, Thyroid receptor-interacting protein 8, Probable JmjC domain-containing histone demethylation protein 2C, JMJD1C Polyclonal Antibody
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