Anti-JAM-A / Junctional adhesion molecule 1, clone RM275 (recombinant antibody)

Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant JAM-A antibody reacts to human JAM1 (Junctional adhesion molecule 1). Protein function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). [The UniProt Consortium]