Anti-IRS-1 (Ab-639)

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit Tzatsos A, et al. (2006) Mol Cell Biol, 26(1): 63-76 Kadowaki T, et al. (2000) J Clin Invest, 106(4): 459-465 Ozes ON, et al. (2001) Proc Natl Acad Sci U S A, 98(8): 4640-4645 Szanto I, et al. (2000) Proc Natl Acad Sci U S A, 97(5): 2355-2360 Protein function: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. [The UniProt Consortium]