Anti-IPO8

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA023765.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA023765.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Seems to function in nuclear protein import, either by acting as autonomous... more

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Product information "Anti-IPO8"

Protein function: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 61% and to rat: 44%

Keywords:	Anti-IPO8, Anti-Imp8, Anti-RanBP8, Anti-RANBP8, Anti-Importin-8, Anti-Ran-binding protein 8
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA023765

Properties

Application:	ICC, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: SNNGRGEDEE EEDDDWDEEV LEETALEGFS TPLDLDNSVD EYQFFTQALI TVQSRDAAWY QLLMAPLSED QRTALQEVYT LAEHRRTVAE AKKKIEQQGG FTFENKGVLS AFNFGTVPSN N (ATA-APrEST73964)