Anti-Interleukin-6 Receptor, gp80, non-neutralizing (CD126, IL-6R), clone 2B2.3

The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci?c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low af?nity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Applications: Suitable for use in Flow Cytometry, ELISA and Immunocytochemistry. Other applications have not been tested. Recommended Dilutions: ELISA (Capture): 1ug/ml. Use with I8428-39D (Detection)., Note: Further dilutions should be made with PBS, 0.1-1% BSA., Optimal dilutions to be determined by the researcher. Hybridoma: (IFFa Credo)/X63-Ag8.653 myeloma cells with spleen cells from Balb/c mice. , , Kd: 1.22nM, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.