Anti-Interleukin 17 Receptor (IL-17R, IL-17RA)

Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine. IL-17 binds to IL-17 receptor (IL-17 R), which shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested. The hIL-17 R gene was localized to chromosome 22. Human IL-17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of hIL-17 R is 69% identical to the mIL-17 R. The signaling events of IL-17 include activation of NF-kB and JNK, and require TNF receptor-associated factor 6 (TRAF6). Applications: Suitable for use in Western Blot, Flow Cytometry and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1ug/ml, Flow Cytometry: 2.5ug/10e6 cells , Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.