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The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. Protein function: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti- inflammatory signaling pathway by recruiting SIGIRR. [The UniProt Consortium]
Keywords:
FIL1D, IL-1F5, IL-1L1, IL-36Ra, IL-1HY1, IL-1RP3, FIL1 delta, IL-1 delta, IL-1ra homolog 1, Interleukin-1 HY1, Interleukin-1 delta, IL-1-related protein 3, Interleukin-1-like protein 1, Interleukin-1 family member 5, IL36RN Polyclonal Antibody
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