Anti-IL33

IL-33 is an IL-1 family cytokine and nuclear alarmin,is constitutively expressed in epithelial barrier tissues and human blood vessels. IL-33 is involved in the maturation of Th2 cells and the activation of mast cells,basophils,eosinophils and natural killer cells. It also acts as a chemoattractant for Th2 cells,and may function as an "alarmin",that amplifies immune responses during tissue injury. Protein function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). [The UniProt Consortium]