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Promotion:
Get 15% Discount on Antibodies and Biosimilars by Abeomics!
*1
*1 Offer expires 30/06/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ABE-10-4167-100 | 100 µg | - |
3 - 11 business days* |
15 %
|
418.00€
355.30€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
IL-36R is a member of the IL-1 receptor family that has been associated with various... more
Product information "Anti-IL-36R (Clone: ABM4B73)"
IL-36R is a member of the IL-1 receptor family that has been associated with various inflammation-associated diseases. Ligands binding to IL-36R subsequently recruit the IL-1RAcP (IL-1 Receptor Accessory Protein) forming a heterodimeric signaling complex. The latter is also used by IL-1Alpha and IL-1 Beta. IL-36R is expressed by different immune cells, including Dendritic Cells, microglia and other myeloid cells. IL-36 stimulation of DC leads to the production of several cytokines by DC, including TNF-a, IL-1, IL-12, and IL-23. This interaction also enhances the expression of MHC class 2 and co-stimulatory molecules. Protein function: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response, it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway. [The UniProt Consortium]
Keywords: | Anti-IL1RL2, Anti-IL-36R, Anti-IL1RRP2, Anti-IL-1Rrp2, Anti-IL1R-rp2, Anti-IL-36 receptor, Anti-Interleukin-1 receptor-like 2, Anti-Interleukin-1 receptor-related protein 2, Monoclonal Antibody to IL-36R (Clone: ABM4B73) |
Supplier: | Abeomics |
Supplier-Nr: | 10-4167 |
Properties
Application: | FC, WB |
Antibody Type: | Monoclonal |
Clone: | ABM4B73 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A partial length recombinant IL-36R protein (amino acids 1-203) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K05172 | Matching products |
UniProt ID : | Q9HB29 | Matching products |
Gene ID | GeneID 8808 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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