Anti-IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)

Recently, IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines has been discovered. IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. IL-23 mediates it cellular function by binding to IL-23 receptor (IL-23R), which pairs with IL-12Rb1 to confer IL-23 responsiveness. However, human IL-12 does not bind to human IL-23R. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12. Applications: Suitable for use in Western Blot, Flow Cytometry, and Immunohistochemistry. Other applications have not been tested. , Recommended Dilution: Western Blot: 0.1-1ug/ml, Immunohistochemistry (Paraffin): 5-10ug/ml, Flow Cytometry: 1:10-1:1000, Optimal dilutions to be determined by the researcher. Positive Control: Jurkat, NIH3T3, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.