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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
I7663-25L6.100 | 100 µg | - | - |
3 - 19 business days* |
901.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also... more
Product information "Anti-IL-1ra (Interleukin-1 Receptor Antagonist Protein, IL-1RN, IL-1ra, IRAP, IL1 Inhibitor, Il1rn)"
IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally-occurring, fully glycosylated form has an apparent molecular weight of about 25kD. The protein shows 26% aa homology to IL-1B and 19% homology to IL-1a. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells. In mouse, IL-1 RII does not bind IL-1ra. The recombinant, non-glycosylated form of IL-1ra blocks binding of IL-1 to its receptor equally as well as the naturally-occurring, glycosylated form. The IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Pre-clinical and clinical studies were done to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-Il1rn, Anti-mCG_4837, Anti-IL-1 receptor antagonist isoform, Anti-Interleukin 1 receptor antagonist |
Supplier: | United States Biological |
Supplier-Nr: | I7663-25L6 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 12K110 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | mouse |
Immunogen: | Recombinant corresponding to aa8-159 from mouse IL-1ra expressed in E.coli. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05481 | Matching products |
UniProt ID : | Q542W1 | Matching products |
Gene ID | GeneID 16181 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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