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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ5375 | 100 µl | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. This gene encodes a... more
Product information "Anti-IGF2R / M6PR, clone DIC-9"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. [RefSeq] Protein function: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). [The UniProt Consortium]
Keywords: | Anti-M6PR, Anti-MPRI, Anti-CD222, Anti-IGF2R, Anti-CI-MPR, Anti-MPR 300, Anti-M6P/IGF2R, Anti-IGF-II receptor, Anti-M6P/IGF2 receptor, Anti-CI Man-6-P receptor, Anti-300 kDa mannose 6-phosphate receptor, Anti-Insulin-like growth factor 2 receptor, IGF2R A |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ5375 |
Properties
Application: | IHC (paraffin), WB |
Antibody Type: | Monoclonal |
Clone: | DIC-9 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A synthetic peptide specific to human M6PR / IGF2R |
Format: | Purified |
Database Information
KEGG ID : | K06564 | Matching products |
UniProt ID : | P11717 | Matching products |
Gene ID | GeneID 3482 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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