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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA002548.25 | 25 µl | - |
7 - 10 business days* |
335.00€
|
|||
ATA-HPA002548.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent... more
Product information "Anti-HUWE1"
Protein function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15989957, PubMed:19713937, PubMed:15567145, PubMed:15767685, PubMed:18488021, PubMed:17567951, PubMed:19037095, PubMed:20534529). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 99% and to rat: 86%
Keywords: | Anti-Mule, Anti-HUWE1, Anti-LASU1, Anti-URE-B1, Anti-HectH9, Anti-ARF-BP1, Anti-HSPC272, Anti-KIAA0312, EC=2.3.2.26, Anti-ARF-binding protein 1, Anti-URE-binding protein 1, Anti-Large structure of UREB1, Anti-Mcl-1 ubiquitin ligase E3 |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA002548 |
Properties
Application: | ICC, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: SGSSTTRLTQ GIGRSQRTLR QLTANTGHTI HVHYPGNRQP NPPLILQRLL GPSAAADILQ LSSSLPLQSR GRARLLVGND DVHIIARSDD ELLDDFFHDQ STATSQAGTL SSIPTALTRW TEECKVLDAE SMHDCVSVVK VSIVNHLE (ATA-APrEST74283) |
Database Information
KEGG ID : | K10592 | Matching products |
UniProt ID : | Q7Z6Z7 | Matching products |
Gene ID | GeneID 10075 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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