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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-43-1040-100 | 100 µg | - |
3 - 11 business days* |
443.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The IT2.2 antibody reacts with human CD86, also known as B7-2, an 80 kDa cell surface protein... more
Product information "Anti-Human CD86 (B7-2) NALE(TM) Purified (Clone: IT2.2)"
The IT2.2 antibody reacts with human CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The IT2.2 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells. It is reported to be cross-reactive with Rhesus, Cynomolgus and Common marmoset CD86. Protein function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. [The UniProt Consortium]
Keywords: | Anti-B70, Anti-BU63, Anti-CD86, Anti-FUN-1, Anti-CD28LG2, Anti-Activation B7-2 antigen, Anti-CTLA-4 counter-receptor B7.2, Anti-T-lymphocyte activation antigen CD86, Monoclonal Antibody to Human CD86 (B7-2) NALE(TM) Purified (Clone: IT2.2) |
Supplier: | Abeomics |
Supplier-Nr: | 43-1040 |
Properties
Application: | FA |
Antibody Type: | Monoclonal |
Clone: | IT2.2 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05413 | Matching products |
UniProt ID : | P42081 | Matching products |
Gene ID | GeneID 942 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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