Anti-Human CD57 NALE(TM) Purified (Clone: TBO1)

The TBO1 monoclonal antibody specifically binds to human CD57, a 110 kDa glycoprotein expressed on a subset of natural killer lymphocytes, cells, neural cells and striated muscle. It is reported that the molecule is involved in cell-matrix interactions and is upregulated in some disease states. Protein function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. [The UniProt Consortium]