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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-AB-F1195E.200 | 200 tests | - |
7 - 16 business days* |
190.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the... more
Product information "Anti-Human CD28, APC conjugated, clone CD28.2"
CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. Protein function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). [The UniProt Consortium]
Keywords: | Anti-CD28, Anti-TP44, Anti-T-cell-specific surface glycoprotein CD28, APC Anti-Human CD28 Antibody[CD28.2] |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-F1195E |
Properties
Application: | FC, FC (membrane) |
Antibody Type: | Monoclonal |
Clone: | CD28.2 |
Conjugate: | APC |
Host: | Mouse |
Species reactivity: | human |
Database Information
KEGG ID : | K06470 | Matching products |
UniProt ID : | P10747 | Matching products |
Gene ID | GeneID 940 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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