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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-AB-F1133D.200 | 200 tests | - |
7 - 16 business days* |
309.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a... more
Product information "Anti-Human CD274/PD-L1, PE conjugated, clone 29E.2A3"
CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-gamma production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. Protein function: Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). [The UniProt Consortium]
Keywords: | Anti-B7H1, Anti-CD274, Anti-PD-L1, Anti-B7-H1, Anti-hPD-L1, Anti-B7 homolog 1, Anti-PDCD1 ligand 1, Anti-Programmed death ligand 1, Anti-Programmed cell death 1 ligand 1, PE Anti-Human CD274/PD-L1 Antibody[29E.2A3] |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-F1133D |
Properties
Application: | FC, FC (membrane) |
Antibody Type: | Monoclonal |
Clone: | 29E.2A3 |
Conjugate: | Phycoerythrin |
Host: | Mouse |
Species reactivity: | human |
Database Information
KEGG ID : | K06745 | Matching products |
UniProt ID : | Q9NZQ7 | Matching products |
Gene ID | GeneID 29126 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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