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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-10-3513-100 | 100 µg | - |
3 - 11 business days* |
2,558.00€
|
|||
ABE-10-3513-500 | 500 µg | - |
3 - 11 business days* |
2,558.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The monoclonal antibody 10-3513 reacts with human RP105 (CD180). RP105 is a type 1 transmembrane... more
Product information "Anti-Human CD180 (Clone-MHR73)"
The monoclonal antibody 10-3513 reacts with human RP105 (CD180). RP105 is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. RP105 expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (MHR73) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule CD80, revealing RP105 as a potent regulator of B-cell activation. In this context it is important to note that RP105 is associated with MD1, and that it mediates B-cell surface expression and LPS recognition and signalling in cooperation with TLR4. MD-1 seems to be requisite for efficient expression of RP105. Protein function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. [The UniProt Consortium]
Keywords: | Anti-LY64, Anti-CD180, Anti-CD180 antigen, Anti-Lymphocyte antigen 64, Anti-Radioprotective 105 kDa protein, Monoclonal Antibody to Human CD180 (Clone-MHR73) |
Supplier: | Abeomics |
Supplier-Nr: | 10-3513 |
Properties
Application: | FC, FA, IP, IHC |
Antibody Type: | Monoclonal |
Clone: | MHR73 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Format: | Purified |
Database Information
KEGG ID : | K06555 | Matching products |
UniProt ID : | Q99467 | Matching products |
Gene ID | GeneID 4064 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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