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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-AB-F1117H.200 | 200 tests | - |
7 - 16 business days* |
392.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD123 is the 70 kD transmembrane alpha chain of the IL-3 receptor. Alone, CD123 binds IL-3 with... more
Product information "Anti-Human CD123, PE/Cyanine7 conjugated, clone 6H6"
CD123 is the 70 kD transmembrane alpha chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity, when CD123 associates with CDw131 (common beta chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the beta chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells. Protein function: Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. [The UniProt Consortium]
Keywords: | Anti-IL3R, Anti-CD123, Anti-IL3RA, Anti-IL-3RA, Anti-IL-3R-alpha, Anti-IL-3R subunit alpha, Anti-IL-3 receptor subunit alpha, Anti-Interleukin-3 receptor subunit alpha, PE/Cyanine7 Anti-Human CD123 Antibody[6H6] |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-F1117H |
Properties
Application: | FC, FC (membrane) |
Antibody Type: | Monoclonal |
Clone: | 6H6 |
Conjugate: | PE/Cy7 |
Host: | Mouse |
Species reactivity: | human |
Database Information
KEGG ID : | K04737 | Matching products |
UniProt ID : | P26951 | Matching products |
Gene ID | GeneID 3563 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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