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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-AB-F1149L.200 | 200 tests | - |
7 - 16 business days* |
386.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD... more
Product information "Anti-Human CD107a/LAMP-1, Elab Fluor(R) 488 conjugated, clone H4A3"
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity. Protein function: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis. Also plays an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. [The UniProt Consortium]
Keywords: | Anti-CD107a, Anti-LAMP-1, Anti-CD107 antigen-like family member A, Anti-Lysosome-associated membrane protein 1, Anti-Lysosome-associated membrane glycoprotein 1, Elab Fluor(R) 488 Anti-Human CD107a/LAMP-1 Antibody[H4A3] |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-F1149L |
Properties
Application: | FC, FC (membrane) |
Antibody Type: | Monoclonal |
Clone: | H4A3 |
Conjugate: | EF488 |
Host: | Mouse |
Species reactivity: | human |
Database Information
KEGG ID : | K06528 | Matching products |
UniProt ID : | P11279 | Matching products |
Gene ID | GeneID 3916 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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