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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-42-1280-100 | 100 µg | - |
3 - 11 business days* |
652.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human HSP40/DnaJ proteins comprise a large protein family, members of which feature the J domain... more
Product information "Anti-HSP40, Hdj1 Monoclonal Antibody (Clone: 3B9.E6) - Alkaline Phosphatase"
Human HSP40/DnaJ proteins comprise a large protein family, members of which feature the J domain (named after the bacterial DnaJ protein). The J-domain spans the first 75 N-terminal amino acids and is separated from the C-terminal by a glycine/phenylalanine-rich domain. Members of the HSP40/DnaJ family play diverse roles in many cellular processes, such as folding, translocation, degradation and assembly of multi-protein complexes. In particular, Hdj1, the first human HSP40/DnaJ protein identified, plays an important role in protein translation and folding, as well as in the regulation of HSP70 function. HSP40 stimulates the ATPase activity of HSP70 which in turn causes conformational changes of the unfolded proteins. The HSP40-HSP70-unfolded protein complex further binds to co-chaperones Hip, Hop and HSP90 which leads to protein folding, or components of protein degradation machinery CHIP and BAG-1. Some studies have shown that the difference between HDJ1 and type 1 DNAJ proteins including HDJ2 and yeast YdjI is the result of the possession of a zinc finger domain by the latter, which helps in the function of protein folding. Protein function: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). [The UniProt Consortium]
Keywords: | Anti-DNAJ1, Anti-HSP40, Anti-hDj-1, Anti-DNAJB1, Anti-Human DnaJ protein 1, Anti-Heat shock protein 40, Anti-DnaJ protein homolog 1, Anti-Heat shock 40 kDa protein 1, Anti-DnaJ homolog subfamily B member 1, Anti-HSP40, Hdj1 Monoclonal Antibody (Clone: 3B9 |
Supplier: | Abeomics |
Supplier-Nr: | 42-1280 |
Properties
Application: | WB, IHC, ICC/IF, IP, ELISA |
Antibody Type: | Monoclonal |
Clone: | 3B9.E6 |
Conjugate: | Alkaline Phosphatase |
Host: | Mouse |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant Protein HSP40 (Hdj1) |
Database Information
KEGG ID : | K09507 | Matching products |
UniProt ID : | P25685 | Matching products |
Gene ID | GeneID 3337 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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