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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ5517 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. HSP105 (HEAT-SHOCK 105/110-KD PROTEIN 1),... more
Product information "Anti-HSP105 / HSPH1, clone 3D10"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. HSP105 (HEAT-SHOCK 105/110-KD PROTEIN 1), also called HSPH1 or HSP110, is a protein that in humans is encoded by the HSPH1 gene. Immunohistochemical analysis localizes HSP105 mainly in the cytoplasm. Database analysis indicates that both HSP105 isoforms are highly conserved during evolution. By analysis of radiation hybrids and human/rodent hybrid cell lines, the HSPH1 gene is mapped to chromosome 13. Both HSP105-alpha and HSP105-beta are upregulated in HeLa cells exposed to heat shock. HSP105-alpha, but not HSP105-beta, is also upregulate in response to other cell stresses. Following heat shock, HSP105 relocalizes from a cytoplasmic to perinuclear position. Besides, HSP110 may thus constitute a major determinant for both prognosis and treatment response in colorectal cancer. Protein function: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. [The UniProt Consortium]
Keywords: | Anti-HSPH1, Anti-HSP105, Anti-Antigen NY-CO-25, Anti-Heat shock 110 kDa protein, Anti-Heat shock protein 105 kDa, HSP105 Antibody / HSPH1 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ5517 |
Properties
Application: | WB, IHC (paraffin), IF, FC |
Antibody Type: | Monoclonal |
Clone: | 3D10 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A human recombinant protein (amino acids Y653-D858) |
Format: | Purified |
Database Information
KEGG ID : | K09485 | Matching products |
UniProt ID : | Q92598 | Matching products |
Gene ID | GeneID 10808 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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