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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol... more
Product information "Anti-HSD17B1"
Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy. Protein function: Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH. [The UniProt Consortium]
Keywords: | Anti-E2DH, Anti-E17KSR, Anti-20-alpha-HSD, Anti-17-beta-HSD 1, Anti-Estradiol 17-beta-dehydrogenase 1, Anti-20 alpha-hydroxysteroid dehydrogenase, Anti-17-beta-hydroxysteroid dehydrogenase type 1, Anti-Placental 17-beta-hydroxysteroid dehydrogenase, HSD17 |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-65790 |
Properties
Application: | IHC, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant fusion protein of human HSD17B1 (NP_000404.2). |
Database Information
KEGG ID : | K00044 | Matching products |
UniProt ID : | P14061 | Matching products |
Gene ID | GeneID 3292 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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