Anti-Hsc70

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG22290.50	50 µl		-	-	6 - 14 business days*		520.00€

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Protein function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional... more

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Product information "Anti-Hsc70"

Protein function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP. [The UniProt Consortium]

Keywords:	Anti-HSC70, Anti-LAP-1, Anti-HSPA8, Anti-LPS-associated protein 1, Anti-Heat shock 70 kDa protein 8, Anti-Heat shock cognate 71 kDa protein, Anti-Lipopolysaccharide-associated protein 1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG22290

Properties

Application:	WB, IHC, ICC, IF, IP, BL
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat, hamster
Immunogen:	Synthetic peptide around aa. 650-670 of Human Hsc70
MW:	73 kD
Format:	Purified