Anti-HM13

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA045089.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Catalyzes intramembrane proteolysis of some signal peptides after they have... more

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Product information "Anti-HM13"

Protein function: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 98% and to rat: 98%

Keywords:	Anti-H13, Anti-HM13, Anti-hIMP1, Anti-IMP-1, Anti-MSTP086, Anti-IMPAS-1, EC=3.4.23.-, Anti-Intramembrane protease 1, Anti-Signal peptide peptidase, Anti-Presenilin-like protein 3, Anti-Minor histocompatibility antigen H13
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA045089

Properties

Application:	IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PASFPNRQYQ LLFTQGSGEN KEEIINYEFD TKDLVCLGLS SIVGVWYLLR KHWIANNLFG LAFSLNGVEL LHLNNVSTGC (ATA-APrEST73077)