Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32167-100 | 100 µg | - |
6 - 10 business days* |
585.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of... more
Product information "Anti-Histone H3T11Ph Monoclonal Antibody (RM164)"
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination. Phosphorylation of histone H3 at threonine 11 (H3T11Ph) occurs during mitosis in mammalian cells and localizes to the centromeric regions of chromosomes during metaphase. H3T11 can be phosphorylated by multiple kinases such as PKC-related kinase (PRK1), which mediates androgen-induced phosphorylation of H3T11 at the androgen receptor target genes PSA and KLK2 in LNCaP cells, and checkpoint kinase 1 (Chk1), which phosphorylates H3T11 at the promoter regions of the genes encoding cyclin B1 and Cdk1 in mice. High levels of H3T11Ph in tumor tissue isolated from patients with prostate cancer correlate with high Gleason scores, which are associated with aggressive tumors. Cayman's Histone H3T11Ph Monoclonal Antibody (RM164) can be used for ELISA, multiplex-based assays, and Western blot (WB) applications.Synonyms: H3pT11, H3pThr11, Histone H3 (Phospho-Thr11), Phospho-Histone H3 Threonine 11, Phosphorylated Histone H3 Threonine 11. Immunogen: Peptide corresponding to H3T11Ph. Clone Designation: RM164. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ELISA, multiplex-based assays, WB. Cross Reactivity: (+) H3T11Ph, (-) Other phosphorylated histones.
Keywords: | H3pT11, H3pThr11, Histone H3 (Phospho-Thr11), Phospho-Histone H3 Threonine 11, Phosphorylated Histone H3 Threonine 11 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32167 |
Properties
Application: | ELISA, multiplex, WB |
Antibody Type: | Monoclonal |
Clone: | RM164 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | vertebrates |
Immunogen: | Peptide corresponding to H3T11Ph |
Format: | Purified |
Database Information
KEGG ID : | K11253 | Matching products |
UniProt ID : | P68431 | Matching products |
Gene ID | GeneID 8350 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed