Anti-Histone H3K36Ac Monoclonal Antibody (RM154)

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination. Acetylation of histone H3 at lysine 36 (H3K36Ac) is predominantly localized to the promoters of genes transcribed by RNA polymerase II and is highly conserved in mammals. Cayman's Histone H3K36Ac Monoclonal Antibody (RM154) can be used for chromatin immunoprecipitation (ChIP), ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.Synonyms: Acetylated Histone H3 Lysine 36. Immunogen: Peptide corresponding to H3K36Ac. Clone Designation: RM154. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ChIP, ELISA, ICC, multiplex-based assay, WB. Cross Reactivity: (+) H3K36Ac, (+) H3K36Ac/S31Ph, (-) Unmodified H3K36, (-) Unmodified H3K4Ac, (-) Unmodified K3K9Ac, (-) Unmodified H3K14Ac, (-) Unmodified H3K18Ac, (-) Unmodified H3K23Ac, (-) Unmodified H3K27Ac, (-) Unmodified H3K56Ac, (-) Unmodified H3K79Ac, (-) Unmodified H3K122Ac.