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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V8647-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V8647-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Phosphohistone H3 (PHH3)... more
Product information "Anti-Histone H3 (pSer10), clone PHH3/471R"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Phosphohistone H3 (PHH3) is a marker specific for cells undergoing mitosis. Serine 10 of Histone H3 is phosphorylated in association with mitotic chromatin condensation in late G2 and M phase of the cell cycle and thus, PHH3 can distinguish mitosis from apoptotic nuclei. The range of percentage PHH3 positive tumor nuclei was from 0.0 to 6.6% (median value 0.8%). Increased expression of PHH3 was significantly associated with tumor thickness (p = 0.031), presence of tumor ulceration (p =0.041) and tumor necrosis (p =0.027), but not with Clarks level of invasion. High levels of PHH3 was associated with increased mitotic count (p = 0.003) and high Ki-67 expression (p = 0.002). For central nervous system tumors, melanoma, soft tissue tumors, GIST, etc., PHH3 mAb is helpful for tumor pathological classification and prognosis. Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [The UniProt Consortium]
Keywords: | Anti-H3FF, Anti-H3FA, Anti-H3FK, Anti-H3FI, Anti-H3FJ, Anti-H3FD, Anti-H3FB, Anti-H3FH, Anti-H3FL, Anti-Histone H3/c, Anti-Histone H3/h, Anti-Histone H3/a, Anti-Histone H3/l, Anti-Histone H3/b, Anti-Histone H3.1, Anti-Histone H3/j, Anti-Histone H3/i, Hist |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V8647 |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | PHH3/471R |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A synthetic peptide corresponding to the amino acids surrounding phospho S10 |
Format: | Purified |
Database Information
KEGG ID : | K11253 | Matching products |
UniProt ID : | P68431 | Matching products |
Gene ID | GeneID 8350 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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