Anti-HIF1AN

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA048742.25	25 µl		-		7 - 10 business days*		300.00€
ATA-HPA048742.100	100 µl		-		7 - 10 business days*		421.00€

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Protein function: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain... more

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Product information "Anti-HIF1AN"

Protein function: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 98% and to rat: 98%

Keywords:	Anti-FIH1, Anti-FIH-1, Anti-HIF1AN, EC=1.14.11.30, Anti-Factor inhibiting HIF-1, Anti-Hypoxia-inducible factor 1-alpha inhibitor, Anti-Hypoxia-inducible factor asparagine hydroxylase
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA048742

Properties

Application:	ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: KGYKRCILFP PDQFECLYPY PVHHPCDRQS QVDFDNPDYE RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQE (ATA-APrEST91155)