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This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. Protein function: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. [The UniProt Consortium]
Keywords:
Anti-HHLA2, Anti-HERV-H LTR-associating protein 2, Anti-Human endogenous retrovirus-H long terminal repeat-associating protein 2, HHLA2 Polyclonal Antibody
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