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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay15648-1 | 1 each | - |
6 - 10 business days* |
488.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Hedgehog acyltransferase-like (HHATL) is the mammalian homolog of yeast Gup1 that is encoded by... more
Product information "Anti-HHATL"
Hedgehog acyltransferase-like (HHATL) is the mammalian homolog of yeast Gup1 that is encoded by the HHATL gene in humans. HHATL is a membrane-bound O-acyltransferase (MBOAT) superfamily member and contains multiple transmembrane domains common to this family but lacks acyltransferase function due to a single amino acid substitution of histidine for leucine at position 447. It is localized to the endoplasmic reticulum (ER) and is expressed in the heart, skeletal muscle, and brain. HHATL colocalizes with sonic hedgehog (Shh) and is a negative regulator of Shh N-terminal palmitoylation, a post-translational modification that is critical for Shh signaling in neural development and embryogenesis. Hhatl-/- neonatal mice fail to develop proper suckling ability, leading to malnutrition and death by postnatal day 14. HHATL expression is decreased in six nasopharyngeal carcinoma cell lines, as well as in tissue isolated from patients with nasopharyngeal carcinoma or skin squamous cell carcinoma. Cayman's HHATL Polyclonal Antibody can be used for flow cytometry (FC), immunofluorescence (IF), and Western blot applications. The antibody recognizes HHATL at ~60 kDa from human samples.Synonyms: C3orf3, Glycerol Uptake Transporter Homolog, GUP1, Hedgehog Acyltransferase-like Protein, KIAA1173, MBOAT3, MSTP002, OACT3, Protein-Cysteine N-Palmitoyltransferase HHAT-like Protein. Immunogen: Synthetic peptide from the C-terminal region of human HHAT. MW: ~60 kDa. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: FC, IF, and WB. UniProt Accession #: Q9HCP6.
Keywords: | Anti-HHATL, Anti-C3orf3, Anti-Glycerol uptake/transporter homolog, Anti-Glycerol uptake/transporter homolog, Anti-Hedgehog acyltransferase-like protein, Anti-Hedgehog acyltransferase-like protein, Anti-Protein-cysteine N-palmitoyltransferase HHAT-like pro |
Supplier: | Cayman Chemical |
Supplier-Nr: | 15648 |
Properties
Application: | FC, IF, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide from the C-terminal region of human HHAT |
Format: | Peptide Affinity Purified |
Database Information
KEGG ID : | K24679 | Matching products |
UniProt ID : | Q9HCP6 | Matching products |
Gene ID | GeneID 57467 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H316, H319 |
P Phrases: | P264, P280, P305+351+338, P332+313, P337+313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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