Anti-HEY1

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Discount	Price
ABE-11-12052-100	100 µg		-		3 - 11 business days*		15 %	387.00€ 328.95€

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Protein function: Transcriptional repressor which binds preferentially to the canonical E box... more

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Product information "Anti-HEY1"

Protein function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). [The UniProt Consortium]

Keywords:	Anti-HEY1, Anti-CHF-2, Anti-hHRT1, Anti-HRT-1, Anti-HESR-1, Anti-BHLHB31, Anti-bHLHb31, Anti-HES-related repressor protein 1, Anti-Hairy-related transcription factor 1, Anti-Cardiovascular helix-loop-helix factor 2, Polyclonal Antibody to HEY1
Supplier:	Abeomics
Supplier-Nr:	11-12052

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	A partial length recombinant HEY1 protein (amino acids 65-280) was used as the immunogen for this antibody.
Format:	Purified