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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES11256.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES11256.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for... more
Product information "Anti-HBEGF"
function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.,PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937).,PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.,similarity:Contains 1 EGF-like domain.,subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor., Protein function: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor., [Proheparin-binding EGF-like growth factor]: Cell membrane, Single-pass type I membrane protein.
Keywords: | Anti-DTR, Anti-HBEGF, HBEGF rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES11256 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse |
Immunogen: | Synthesized peptide derived from human protein . at AA range: 130-210 |
MW: | 22 kD |
Format: | Purified |
Database Information
KEGG ID : | K08523 | Matching products |
UniProt ID : | Q99075 | Matching products |
Gene ID | GeneID 1839 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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