Anti-GRP3

RAS guanyl releasing protein 3(RASGRP3) Homo sapiens Members of the RAS (see HRAS, MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008], Protein function: Guanine nucleotide exchange factor (GEF) for Ras and Rap1. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: intracellular,plasma membrane,integral component of plasma membrane,guanyl-nucleotide exchange factor complex,perinuclear region of cytoplasm,