Anti-Grb2 Polyclonal Antibody

Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling. Protein function: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. [The UniProt Consortium]