Anti-GPRC5A / Retinoic acid-induced protein 3 / PEIG-1, clone GPRC5A/7893

1 mg/ml in 1X PBS, BSA free, sodium azide free. Retinoic acid-induced protein 3 (RAI3), also called Phorbol ester induced gene 1 (PEIG-1) and GPRC5A, is an transmembrane G protein-coupled receptor that affects many essential biological processes including embryogenesis, cell growth, differentiation, and apoptosis. PEIG-1 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate PEIG-1 during its transcription in embryonal carcinoma differentiation. PEIG-1 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of PEIG-1 and represses its expression at the beginning of apoptosis. PEIG-1 is a potential molecular target for diagnosing breast cancer, and selective suppression of signals from PEIG-1 may have a place in breast cancer treatments. Protein function: Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor (PubMed:18000218). [The UniProt Consortium]