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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay37008-25 | 25 tests | - |
6 - 10 business days* |
126.00€
|
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Cay37008-100 | 100 tests | - |
6 - 10 business days* |
252.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan. It is composed of a signal... more
Product information "Anti-Glypican-3 Rabbit Monoclonal Antibody (PE) (Clone 024)"
Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan. It is composed of a signal peptide for membrane translocation, a cysteine-rich domain that contains a proteolytic cleavage site for proprotein convertases, a stalk region that contains heparan sulfate attachment sites, and a signal sequence for glycosylphosphatidylinositol (GPI) attachment, which anchors it to the cell surface. GPC3 is ubiquitously expressed during embryonic development and is only expressed in select adult tissues, including gastric glands and kidney tubules. It is involved in canonical and non-canonical Wnt signaling and binds to various Wnt ligands and Frizzled receptors. GPC3-targeting antibodies induce antibody-dependent cellular cytotoxicity (ADCC) and reduce tumor growth in hepatocellular carcinoma (HCC) mouse xenograft models. Hepatic levels of GPC3 are increased in patients with HCC. Mutations in GPC3 are associated with Simpson-Golabi-Behmel syndrome (SGBS), an X-linked condition characterized by pre- and post-natal overgrowth. Cayman's Glypican-3 Rabbit Monoclonal Antibody (PE) (Clone 024) is composed of a GPC3 monoclonal antibody conjugated to phycoerythrin (PE) and can be used for flow cytometry (FC).Synonyms: GPC3, MXR7, OCI-5. Immunogen: A synthetic peptide corresponding to the central region of human glypican-3. Clone Designation: 024. Formulation: (Request formulation change), Protein A-affinity purified monoclonal antibody. Storage Buffer: PBS solution with 0.5% BSA and 0.03% ProClin(TM) 300. Host: Rabbit. Isotype: IgG. Applications: FC. Cross Reactivity: (+) Glypican-3. UniProt Accession #: P51654.
Keywords: | Anti-GPC3, Anti-OCI5, Anti-MXR7, Anti-GTR2-2, Anti-Glypican-3, Anti-Intestinal protein OCI-5, Anti-Glypican-3 beta subunit {ECO:0000303|PubMed:14610063}, Anti-Glypican-3 alpha subunit {ECO:0000303|PubMed:14610063} |
Supplier: | Cayman Chemical |
Supplier-Nr: | 37008 |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | 24 |
Conjugate: | No |
Host: | Rabbit |
Immunogen: | A synthetic peptide corresponding to the central region of human glypican-3 |
Format: | Purified |
Database Information
KEGG ID : | K08109 | Matching products |
UniProt ID : | P51654 | Matching products |
Gene ID | GeneID 2719 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H317, H401, H411 |
P Phrases: | P261, P272, P273, P280, P302+352, P321, P333+313, P362+364, P391, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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