Anti-GLMN

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA031448.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA031448.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box... more

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Product information "Anti-GLMN"

Protein function: [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels. Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 81% and to rat: 77%

Keywords:	Anti-FAP, Anti-GLMN, Anti-Glomulin, Anti-FKBP-associated protein, Anti-FK506-binding protein-associated protein
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA031448

Properties

Application:	WB, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: LSAIGHPFPK MIFNHGRKKR TWNYLEFEEE ENKQLADSMA SLAYLVFVQG IHIDQLPMVL SPLYLLQFNM GHIEVFLQRT EESV (ATA-APrEST77086)