Anti-GDF5

Anti-GDF5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-CAB13167.50 50 µl - -

9 - 20 business days*

352.00€
G-CAB13167.100 100 µl -

9 - 20 business days*

448.00€
 
WB 1:500 - 1:2000, IHC 1:50 - 1:200. Protein function: Growth factor involved in bone and... more
Product information "Anti-GDF5"
WB 1:500 - 1:2000, IHC 1:50 - 1:200. Protein function: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). [The UniProt Consortium]
Keywords: Anti-GDF5, Anti-BMP14, Anti-GDF-5, Anti-LAP-4, Anti-CDMP-1, Anti-BMP-14, Anti-Radotermin, Anti-LPS-associated protein 4, Anti-Bone morphogenetic protein 14, Anti-Growth/differentiation factor 5, Anti-Lipopolysaccharide-associated protein 4, GDF5 Polyclona
Supplier: Assay Genie
Supplier-Nr: CAB13167

Properties

Application: WB, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: mouse, rat

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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